Manganese is considered an essential trace element, of which the average adult needs 2-5mg per day.

Actions of Manganese include:

  • Essential component of carbohydrate metabolism, reproductive function, skeletal and cartilage development.
  • Critical element in metalloenzymes pyruvate decarboxylase and superoxide dismutise that are involved in energy production and immune function.
  • Activates phosphatases, kinases, decarboxylases and glycosyltransferases, facilitating the synthesis of protein and DNA in the production of mucopolysaccharides in cartilage.

Clinical applications:

  • Alcohol detoxification. (Cirrhosis patients may not be able to properly excrete Manganese & should therefore avoid using Manganese supplements).
  • Cartilage: essential for the production of optimal quantities of proteoglycans in cartilage, Osgood-Schlatter disease and Calve-Perth’s disease.
  • Diabetes mellitus: Manganese activates the enzymes involved in the process of glycolysis.
  • Epilepsy: Some forms may occur as a result of Manganese deficiency and Manganese can control seizures (Convulsions) in some cases.
  • Osteoporosis: enhances bone growth by stimulating osteoblasts and suppressing osteoclasts.
  • Tardive dyskinesia: prevention (15 mg/day) and treatment (60 mg/day) in patients taking phenothiazines.

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