Arthritis and Inflammatory Disorders
Arthritis is a condition that involves free radicals and inflammation. By reducing free radicals, inflammation may be eased and relieve arthritic pain.
Many pains besides Arthritis can be caused by Inflammation. Inflammation is characterized by swelling, pain, localized heat, and redness. Injury could be a major catalyst for inflammation. When injury occurs, fluid gets trapped in the spaces between cells in the injured tissue. This fluid most often is the result of leakage from capillaries, but it can also be produced directly in tissue via free radical reactions.
In addition to anti-inflammatory properties, antioxidants like flavonoids may have beneficial effects in arthritic diseases by positively influencing the balance between synthesis and degradation of extra-cellular cartilage constituents. Evidence for this action comes from the inhibition of type II collagen breakdown.
Antioxidants help normalize capillary permeability to prevent the leakage of fluid that causes swelling. It also helps by neutralising free radicals that promote swelling and inflammation. Antioxidants possess multiple anti-inflammatory activities making it an excellent choice as a natural product in the treatment of inflammatory disorders. These conditions include;
- Rheumatoid arthritis
- Juvenile rheumatoid arthritis
- Asthma and severe kidney disease,
- Inflammatory bowel disease (Crohn’s disease & ulcerative colitis)
- Systemic lupus
- Ankylosing spondylitis
- Multiple sclerosis
- Sports injuries
Inflammation Is One Of The Main Drivers Of Disease
In the acute inflammatory response the production of this entire battery of free radicals is an important mechanism that is necessary to fight of invading pathogens. However, the problems begin when the inflammatory process persists and becomes chronic, because the inherently high level of oxidative stress turns against the healthy body tissues. In diseases, such as the different forms of arthritis or in autoimmune disorders like lupus or multiple sclerosis, where inflammation manifests chronically, free radicals are permanently produced and have the capacity to cause tissue destruction. It is in particular in these types of diseases that managing oxidative stress levels should be considered as part of the general therapy.
Why Antioxidants In Support Of Inflammatory Disorders?
Evidence for the role of antioxidants in disorders of chronic inflammation comes from many studies on the consequences of the elevated oxidant levels. Biomarkers of cellular damage indicative of oxidative stress. Antioxidants like flavonoids are uniquely suited as a support or single therapy in the treatment of inflammatory disorders due to their combination of super powerful antioxidant and anti-inflammatory properties.
Reasons Why Antioxidants Are Beneficial
The reasons to use antioxidants in the management of inflammatory disorders include:
- In addition to anti-inflammatory properties flavonoids may also have beneficial effects in arthritic diseases by positively influencing the balance between synthesis and degradation of extra-cellular cartilage constituents. This basically means that Evidence for this action comes from inhibition of type II collagen breakdown.
- The radical scavenging capacity of flavonoids, and particularly proanthocyanidins is many times higher than that of the vitamin antioxidants for a wide range of radicals.
- The potency as antioxidants and the chemical diversity of multi-compound flavonoid extracts strongly recommend flavonoids in therapeutic efforts to lower oxidative stress levels.
- Flavonoids have been shown to inhibit the production of ROS (Reactive Oxygen Species), the activity of the ROS generating enzymes MPO and NADPH oxidase, and several signal transducing enzymes involved in the cell activation in neutrophils.
- Flavonoids have been shown to reduce biomarkers of oxidative cell damage in cell culture systems, animal models and human studies.
- Flavonoids inhibit lipid peroxidation this can be by direct radical scavenging or by chelation properties of transition metals.
- Flavonoids have direct anti-inflammatory properties that have been documented in many studies. The anti-inflammatory properties of flavonoids include cyclooxygenase.
Antioxidants including flavonoids are very promising agents for the management of arthritis and other inflammatory diseases. In addition, flavonoids possess multiple anti-inflammatory activities making it an excellent choice as a support agent in the treatment of inflammatory disorders.