How Do Probiotics Work?

Why Probiotics?

We already have billions of bacteria living in our gut. Some are harmful (pathogenic), but many are beneficial. As clinicians we know that keeping a balance between the good and the bad bacterial is critical to maintaining our good health. Probiotics not only help keep bad bacteria and yeast from growing in our GI tract, they confer many other proven benefits to us. Researchers believe that probiotics work as a result of several likely complex and interacting mechanisms such as the stimulation of mucin production, competition for binding sites to the intestinal wall, producing antimicrobial substances such as acidophillin, improvement in gut transit time, improved production and metabolism of many nutrients, improved regulation of the immune system, delivery of proteins and by stabilizing the gut mucosal barrier. Because a person’s native micro-flora are well adapted to suit a person’s inner environment, and because many species adapt and become resistant to change, probiotics generally have not shown to have a consistent or significant impact across a broad range of populations.

Many believe that probiotics have a significant effect on improving the populations of a person’s intestinal microbes, when in fact many of a probiotic supplement’s effects are in fact are very transient. This is most likely due to the fact that a person’s native micro-flora have become well adapted and stable enough to resist change. What has been shown however is that probiotics have more of an impact on the actual biochemistry of the GI environment, and when probiotics are given during periods of disruption (such as antibiotics) they seem to provide opportunity to positively influence a person’s health.

Dr. Khem Shahani

Dr. Khem Shahani

Lactobacillus acidophilus DDS-1

Regardless of which strains you decide to use in your clinic, Lactobacillus acidophilus is still the most important of the probiotics to recommend and prescribe. I have incorporated Lactobacillus acidophilus DDS-1 into my unique formulation called CanXida Restore.

I believe in excellence in nutritional supplementation, and in order for me to be able to recommend a premium probiotic product to you with complete confidence, it is important for us to source the very best raw materials I can find. I am pleased to inform you that my probiotic raw materials are sourced only from Nebraska Cultures, the world leader, pioneer and innovator in probiotic supplementation. Why would I want to supply my patients with probiotics of any lesser quality? Dr. Khem Shahani first started to research probiotics in the 1950’s, in a time when nobody in the dietary supplement industry understood the importance of Lactobacillus and human health. After more than forty years of lactobacillus research, Dr. Shahani sought to manufacture and perfect the most stable, bioactive and potent form of Lactobacillus, the Lactobacillus acidophilus DDS-1. Dr. Shahani explains that in ideal conditions, one single DDS-1 organism multiplies every twenty minutes in the small intestine, creating an incredible 1 million micro-organisms in only seven hours.

Is Your Current Probiotic

  • Stable at normal room temperatures for two years?
  • Manufactured from a human strain of Lactobacillus?
  • Manufactured using a patented antibiotic-resistant process?
  • Backed by over 200 published papers and 40 years of scientific research?
  • Naturally bile and acid resistant to survive the stomach and intestinal transit?
  • Manufactured using a patented cryo-protective process? (air, heat, moisture & light protection)
  • Produced by the pioneer in probiotic supplementation, Dr. Khem Shahani?

Key Points of the Lactobacillus DDS-1 Strain (based on documented research)

  • Helps digest proteins and carbohydrates
  • Produces the B vitamins pantothenic acid, pyridoxine, niacin, folic acid, cobalamin and biotin, in addition to vitamin K.
  • Produces many enzymes, including lactase that helps reduce lactose intolerance
  • Produces natural beneficial acids that help digest food and fight infection
  • Produces natural antibiotic-like acidophilin that kills many forms of pathogenic bacteria
  • Suppresses bad bacteria that cause skin problems, bad breath, constipation & diarrhea, flatulence & bloating, stomach ulcers.
  • Helps the body to absorb calcium
  • Inhibits multiplication of cancerous cells
  • Reduces serum LDL cholesterol levels
  • Improves skin conditions such as eczema and asthma
  • Stimulates many aspects of the immune system

The following You Tube will help you to become familiar with Dr. Khem Shahani, at Nebraska Cultures.

General Applications for Probiotics

It was always generally thought that probiotics were only a beneficial dietary supplement for those with digestive problems, especially with diarrhea after antibiotic administration. After much clinical research, today we know different. Probiotics play a vital role in the healthy operation many of our body’s functions.  Here are some of the most common and well-researched problems that can benefit from probiotic supplementation:

Digestion And Metabolism

  • All digestive and gastrointestinal problems – to improve all parameters of GI health. Constipation, diarrhea, flatulence, bloating, symptoms of IBS as well as IBD are some of the most common gastrointestinal complaints which probiotics you may well use probiotics for. Probiotics are safe and effective at helping to treat these all these problems without side effects.
  • After antibiotics or for those who eat poultry or eggs – to counter antibiotic induced damage. Probiotics are known to be one of the most important dietary supplements to give after antibiotics. But what about antibiotics commonly used today in commercial poultry and egg production? Dr. Shahani’s Lactobacillus acidophilus DDS-1 (human) strain is the only known probiotic which has antibiotic resistance. A patent was filed in 1972 by Dr. Shahani to protect his unique antibiotic resistant probiotic development process. Only the DDS-1 strain is known to have this strong resistance to penicillin.
  • Leaky gut syndrome and any food allergies – to improve intestinal barrier permeability. Many species of probiotics are able to stimulate the production of intestinal mucus secretions and even inhibit entero-hemorrhagic coli. Probiotics decrease bacterial adhesion, secrete repair factors and stimulate the production of sIgA. Mack and colleagues showed in a 2003 paper that various probiotics are able to positively influence the intestinal production of mucin.
  • Milk or dairy intolerances – to improve the digestion of lactose. In Cultivate Health from Within, Dr. Shahani reveals studies that prove the ability of the L. acidophilus DDS-1 probiotic to help produce the enzyme lactase to facilitate in the digestion of lactose. A 1990 paper by Marteau et al. explains in detail how lactobacillus acidophilus benefits those who are lactose intolerant.

Immune Benefits

  • Improve and control many immune problems – improves cell mediated & humoral response. Since the intestine is the body’s largest immune system organ, its ability to efficiently respond to immune attacks is directly related to its balance of healthy bacteria. Regular probiotic supplementation has been shown to maintain intestinal health and enhance natural immune system response by stimulating the body’s production of NK and T-cells.
  • Antiviral effects. Probiotics such as acidophilus have been shown to inactivate many different viruses. This has been postulated as being due to being able to lower pH and produce anti-viral by-products or a combination of these.
  • Helps reduce inflammation. Probiotics help to balance and manage pro and anti-inflammatory cytokines. A 2006 study revealed that lactobacillus can successfully decrease the inflammatory response in Crohn’s disease. Many studies show a positive correlation between probiotics and a reduction in inflammation.
  • Infections – to suppress bad bacteria. A safer and more effective way of eliminating bad bacteria in the body is by overpowering it with good bacteria. By regularly supplementing with a maintenance dose of probiotics, there’s little room for unfriendly bacteria to settle in.
  • Candida – to fight candida yeast and fungal infections. Today’s diets rich in sugar, processed foods, cortisone-like drugs, birth control pills, immunosuppressive drugs and antibiotics, have been major culprits in the candida epidemic of today. In Cultivate Health from Within, Dr. Shahani reveals studies that prove the ability of probiotics to stimulate the production of white blood cells in the body that combat candida yeast and fungal infections.
  • Immune-boosting – to produce natural antibiotic-like substances. Lactobacillus acidophilus DDS-1 has been shown in documented research to produce the natural antibiotic-like substance acidophilin that kills pathogenic bacteria.  Mishra and Lambert in a 1996 study showed that several probiotic bacteria have shown to produce a wide range of antimicrobial agents including organic acids (lactic and acetic acid) as well as hydrogen peroxide, carbon dioxide, diacetyl as well as bacteriocidins and bacteriocidin like substances.
  • Cancer prevention – to inhibit tumors and carcinogenesis. In lab studies, the DDS-1 strain of Lactobacillus acidophilus has been shown to inhibit tumor growth and block the formation of carcinogenic compounds in laboratory animals.

Miscellaneous Health Benefits

  • Bone metabolism and osteoporosis – to enhance calcium metabolism. In laboratory studies, the DDS-1 strain of Lactobacillus acidophilus has been shown to increase the body’s ability to absorb and metabolize calcium. This is an incredible advantage for individuals suffering from bone density loss such as osteoporosis and osteopenia.  This is also of great benefit for growing young adults and expectant mothers who need lots of calcium.
  • B Vitamin production – to produce B vitamins naturally. Acidophilus DDS-1 has been shown to produce B vitamins (pantothenic acid, pyridoxine, niacin, folic acid, cobalamin and biotin), in addition to vitamin K, which support and increase the rate of metabolism, help maintain healthy skin and muscle tone, and enhance nervous and circulatory system function.  Folic acid is essential for children, adults, and especially expectant mothers.
  • Healthy weight – to enhance weight loss & weight maintenance programs. In Cultivate Health from Within, Dr. Shahani’s book, he reveals the research that shows that a major factor in maintaining ideal body weight is to make sure that your digestive system is functioning properly. A healthy digestive system will help to increase energy and improve metabolism.
  • Heart disease – to reduce cholesterol in the blood. In Dr. Shahani’s book, Cultivate Health from Within, he reveals studies that show that the DDS-1 strain of L. acidophilus is a proven aid in the digestion of fats that contribute to the levels of LDL and HDL cholesterol in the blood.  Consumption of the DDS-1strain of L. acidophilus has been associated with the lowering of LDL levels and the increasing of HDL levels in the blood.
  • Skin health – to help reduce many kinds of skin problems. Probiotics have been shown to help alleviate skin problems such as acne, psoriasis, and eczema.
  • Detoxification – to help improve liver function. By detoxifying the blood; bifidum and other probiotics may help the liver to perform more efficiently and with less strain.

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